Pd(II)-Catalyzed One-Pot, Three-Step Route for the Synthesis of Unsymmetrical Acridines

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• 作者：Hai-Ming Guo ; Run-Ze Mao ; Qiao-Tian Wang ; Hong-Ying Niu ; Ming-Sheng Xie ; Gui-Rong Qu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 1, 2013
• 年：2013
• 卷：15
• 期：21
• 页码：5460-5463
• 全文大小：258K
• 年卷期：v.15,no.21(November 1, 2013)
• ISSN：1523-7052

文摘

Unsymmetric acridines are synthesized via a one-pot amination/cyclization/aromatization reaction for the first time. With Pd(OAc)₂-X-Phos as the catalyst, a series of unsymmetric acridines are obtained in moderate to excellent yields (up to 99% yield). Meanwhile, the diphenylamine intermediate could be isolated, which is evidence of the domino process.