Microwave-Assisted Esterification: A Discovery-Based Microscale Laboratory Experiment

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• 作者：Maureen K. Reilly ; Ryan P. King ; Alexander J. Wagner ; Susan M. King
• 刊名：Journal of Chemical Education
• 出版年：2014
• 出版时间：October 14, 2014
• 年：2014
• 卷：91
• 期：10
• 页码：1706-1709
• 全文大小：187K
• ISSN：1938-1328

文摘

An undergraduate organic chemistry laboratory experiment has been developed that features a discovery-based microscale Fischer esterification utilizing a microwave reactor. Students individually synthesize a unique ester from known sets of alcohols and carboxylic acids. Each student identifies the best reaction conditions given their particular reagents (either excess alcohol or excess carboxylic acid) as well as the ideal workup procedure for their reaction. Products are analyzed using ¹H NMR spectroscopy, IR spectroscopy, and scent. This modern adaptation of the classic Fischer esterification provides the opportunity for discussion of important chemistry concepts, including acid catalysis, Le Ch芒telier鈥檚 principle, and green chemistry.

Keywords:

Second-Year Undergraduate; Laboratory Instruction; Organic Chemistry; Hands-On Learning/Manipulatives; Inquiry-Based/Discovery Learning; Esters; Microscale Lab; Green Chemistry; NMR Spectroscopy; IR Spectroscopy