A Concise Total Synthesis of the Lichen Macrolide (+)-Aspicilin

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• 作者：Christophe Dubost ; Istvá ; n E. Markó ; Thomas Ryckmans
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：October 26, 2006
• 年：2006
• 卷：8
• 期：22
• 页码：5137 - 5140
• 全文大小：86K
• 年卷期：v.8,no.22(October 26, 2006)
• ISSN：1523-7052

文摘

The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation ofaldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield.