Use of Calorimetry Model and Batch Control Technique for Scale-Up of Unseeded Batch Cooling Crystallization of Poly(hydroxybenzophenone)

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• 作者：Huiyong Kim ; Yookyung Bang ; Kwang Soon Lee ; Dae Ryook Yang
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2009
• 出版时间：July 15, 2009
• 年：2009
• 卷：48
• 期：14
• 页码：6776-6782
• 全文大小：277K
• 年卷期：v.48,no.14(July 15, 2009)
• ISSN：1520-5045

文摘

A scale-up method to design and implement a cooling profile for unseeded batch cooling crystallization has been investigated. The reduced ratio between the heat-transfer area and the volume during scale-up to a large crystallizer causes an increase in the temperature distribution in the reactor, which can trigger unwanted nucleation around the cold spots of the vessel wall. To address this problem, a method is proposed to design a cooling profile for a scaled-up crystallizer that can replicate the seed-generation stage of a small crystallizer by effectively suppressing the unwanted nucleation. The use of a batch control technique as method of implementing the cooling profile in a large crystallizer is also proposed. Experiments were conducted with a 100 mL reactor and a 5 L scaled-up reactor for the unseeded crystallization of poly(hydroxybenzophenone) (PHBP) to verify the performance of the proposed method.