Sacchathridine A, a Prostaglandin Release Inhibitor from Saccharothrix sp.

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• 作者：Koichi Nakae ; Ikuko Kurata ; Fukiko Kojima ; Masayuki Igarashi ; Masaki Hatano ; Ryuichi Sawa ; Yumiko Kubota ; Hayamitsu Adachi ; Akio Nomoto
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：720-722
• 全文大小：197K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E₂ release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC₅₀ value of 1.0 渭M, but had no effect on cell growth up to 30 渭M.