Straightforward ARGET ATRP for the Synthesis of Primary Amine Polymethacrylate with Improved Chain-End Functionality under Mild Reaction Conditions

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• 作者：Patr铆cia V. Mendon莽a ; Saadyah E. Averick ; Dominik Konkolewicz ; Arm茅nio C. Serra ; Anatoliy V. Popov ; Tamaz Guliashvili ; Krzysztof Matyjaszewski ; Jorge F. J. Coelho
• 刊名：Macromolecules
• 出版年：2014
• 出版时间：July 22, 2014
• 年：2014
• 卷：47
• 期：14
• 页码：4615-4621
• 全文大小：380K
• ISSN：1520-5835

文摘

Activators regeneration by electron transfer atom transfer radical polymerization (ARGET ATRP) of 2-aminoethyl methacrylate hydrochloride (AMA) was successfully performed for the first time. The polymerizations were conducted at 35 掳C in isopropanol (IPA)/water mixtures or pure water, using CuBr₂/TPMA (TPMA: tris(2-pyridylmethyl)amine) as a metal catalyst complex with slow feeding of ascorbic acid (AscA) to allow regeneration of the activator species. The reactions showed first-order kinetics with monomer conversion and high monomer conversion (>90%), and controlled polymers (膼 鈮?1.3) were obtained using optimized conditions. For the first time, as a result of the PAMA鈥檚 high chain-end functionality, it was possible to extend the polymer and synthesize a well-defined block copolymer (PAMA-b-POEOMA) (OEOMA: oligo(ethylene oxide) methyl ether methacrylate) by ATRP techniques, using AMA as the first block. PAMA-based nanogels, with potential biomedical applications, were prepared by ARGET ATRP in inverse miniemulsion.