Biofunctionalized Rebar Graphene (f-RG) for Label-Free Detection of Cardiac Marker Troponin I

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• 作者：Satish K. Tuteja ; Priyanka Sabherwal ; Akash Deep ; Richa Rastogi ; Ashok K. Paul ; C. Raman Suri
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2014
• 出版时间：September 10, 2014
• 年：2014
• 卷：6
• 期：17
• 页码：14767-14771
• 全文大小：330K
• ISSN：1944-8252

文摘

One-step microwave-assisted unscrolling of carbon nanotubes to form functionalized rebar graphene (f-RG) is reported. The well-characterized f-RG on an interdigitated electrode biochip in a FET configuration showed enhanced electronic properties, as demonstrated with I鈥?i>V characteristics. The developed device was biofunctionalized with specific anti-cTnI antibodies exhibiting a shift of threshold voltage from 鈭?.15 V to 鈭?.5 V and decrease in electron mobility from 3.609 脳 10⁴ to 8.877 脳 10³ cm² V^鈥? s^鈥?. The new sensing strategy holds great promise for its applicability in diagnostics exhibiting high sensitivity (鈭? pg/mL) and specificity toward cardiac marker (cTnI).

Keywords:

functionalized rebar graphene; carbon nanotubes; biochip; cardiac marker; troponin I; clinical diagnostics