Total Synthesis of Gymnocin-A

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• 作者：Takeo Sakai ; Shingo Matsushita ; Shogo Arakawa ; Koichi Mori ; Miki Tanimoto ; Akihiro Tokumasu ; Tatsuji Yoshida ; Yuji Mori
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：November 18, 2015
• 年：2015
• 卷：137
• 期：45
• 页码：14513-14516
• 全文大小：514K
• ISSN：1520-5126

文摘

A convergent total synthesis of cytotoxic marine natural polycyclic ether, gymnocin-A (1), is described. The synthesis features three iterations of an oxiranyl anion strategy, involving base-mediated cycloetherification, ring expansion, and reductive etherification, for the construction of the FGH fragment and for its coupling with the ABC and KLMN fragments.