Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies

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• 作者：Asiri Ediriwickrema ; W. Mark Saltzman
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2015
• 出版时间：February 9, 2015
• 年：2015
• 卷：1
• 期：2
• 页码：64-78
• 全文大小：485K
• ISSN：2373-9878

文摘

Cancer continues to be a prevalent and lethal disease, despite advances in tumor biology research and chemotherapy development. Major obstacles in cancer treatment arise from tumor heterogeneity, drug resistance, and systemic toxicities. Nanoscale delivery systems, or nanotherapies, are increasing in importance as vehicles for antineoplastic agents because of their potential for targeting and multifunctionality. We discuss the current field of cancer therapy and potential strategies for addressing obstacles in cancer treatment with nanotherapies. Specifically, we review the strategies for rationally designing nanoparticles for targeted, multimodal delivery of therapeutic agents.