Multistep Microwave-Assisted Divergent Synthesis of Indolo-Fused Pyrazino-/Diazepinoquinoxalinones on PEG Support

详细信息    查看全文

• 作者：Jin-Ji Lai ; Deepak B. Salunke ; Chung-Ming Sun
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2174-2177
• 全文大小：252K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

Synthesis of amino acid and indoline-substituted dinitrobenzene on a soluble polymer support (PEG) and its further reductive double-ring closure to afford structurally diverse indolo-fused pyrazino-/diazepinoquinoxalinones is described. Traceless synthesis of quinoxalinones coupled with application of the Pictet−Spengler-type condensation reaction furnished these novel scaffolds. These hitherto novel heterocycles are synthesized in shorter times under microwave irradiation conditions in comparison with that of classical reaction conditions.