A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion

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• 作者：Yulan Wang ; Huiru Tang ; Jeremy K. Nicholson ; Peter J. Hylands ; J. Sampson ; and Elaine Holmes
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：January 26, 2005
• 年：2005
• 卷：53
• 期：2
• 页码：191 - 196
• 全文大小：85K
• 年卷期：v.53,no.2(January 26, 2005)
• ISSN：1520-5118

文摘

A metabonomic strategy, utilizing high-resolution ¹H NMR spectroscopy in conjunction with chemometric methods (discriminant analysis with orthogonal signal correction), has been applied to thestudy of human biological responses to chamomile tea ingestion. Daily urine samples were collectedfrom volunteers during a 6-week period incorporating a 2-week baseline period, 2 weeks of dailychamomile tea ingestion, and a 2-week post-treatment phase. Although strong intersubject variationin metabolite profiles was observed, clear differentiation between the samples obtained before andafter chamomile ingestion was achieved on the basis of increased urinary excretion of hippurate andglycine with depleted creatinine concentration. Samples obtained up to 2 weeks after daily chamomileintake formed an isolated cluster in the discriminant analysis map, from which it was inferred that themetabolic effects of chamomile ingestion were prolonged during the 2-week postdosing period. Thisstudy highlights the potential for metabonomic technology in the assessment of nutritional interventions,despite the high degree of variation from genetic and environmental sources.Keywords: NMR-based metabonomics; chamomile; Matricaria recutita L.; orthogonal signal correction