Synthesis and Cytotoxic Evaluation of Some Cribrostatin–Ecteinascidin Analogues

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• 作者：Benjamin J. D. Wright ; Collin Chan ; Samuel J. Danishefsky
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：71
• 期：3
• 页码：409 - 414
• 全文大小：144K
• 年卷期：v.71,no.3(March 2008)
• ISSN：1520-6025

文摘

Analogues of cribrostatin IV (1) and the potent antineoplastic agent ecteinascidin 743 (2) have been synthesized. The cytotoxic activity of these compounds (5, 14, 20) has been determined, and the cyanoamine−cribrostatin analogue (14) exhibits a 20-fold improvement with regard to the natural product 1.