A Cooperative Participation of the Amido Group in the Organocatalytic Construction of All-Carbon Quaternary Stereocenters by Michael Addition with 尾-Ketoamides
详细信息 查看全文
- 作者：Maria del Mar Sanchez Duque ; Olivier Basle虂 ; Nicolas Isambert ; Anouk Gaudel-Siri ; Yves Ge虂nisson ; Jean-Christophe Plaquevent ; Jean Rodriguez ; Thierry Constantieux
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：July 1, 2011
- 年：2011
- 卷：13
- 期：13
- 页码：3296-3299
- 全文大小：757K
- 年卷期：v.13,no.13(July 1, 2011)
- ISSN：1523-7052
文摘
The secondary amido group of 伪-substituted 尾-ketoamides plays a crucial role in the control of the reactivity and spatial arrangement (selectivity) in the organocatalyzed Michael addition to unsaturated carbonyls. This results in an unprecedented activation mode of substrates through H-bonding interactions allowing the construction of enantiomerically enriched functionalized all-carbon quaternary centers and spiroaminals of high synthetic potential.