Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

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• 作者：Sabah El-Ghaiesh ; Joseph P. Sanderson ; John Farrell ; Sidonie N. Lavergne ; Wing-Kin Syn ; Munir Pirmohamed ; B. Kevin Park ; Dean J. Naisbitt
• 刊名：Chemical Research in Toxicology
• 出版年：2011
• 出版时间：June 20, 2011
• 年：2011
• 卷：24
• 期：6
• 页码：791-793
• 全文大小：726K
• 年卷期：v.24,no.6(June 20, 2011)
• ISSN：1520-5010

文摘

Pathways of drug-specific T-cell stimulation have not been fully defined. The aim of this study was to use T-cell clones from a patient hypersensitive to the drug trimethoprim to characterize the involvement of drug metabolism and processing in antigen presentation and cross-reactivity patterns. The MHC-restricted CD4+ and CD8+ T-cell response was dependent on the presence of antigen-presenting cells, and both processing-dependent and -independent pathways of antigen presentation were detected. Stimulation of certain clones was blocked through inhibition of drug-metabolizing enzyme activity. Trimethoprim clones were additionally stimulated with diaveridine and pyrimethamine but not other closely related structures.