文摘
The work describes the synthesis and in vivo application of [Gd(L)(H2O)]路xH2O, where L is a (125I/127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a 鈥渃ocktail mixture鈥?of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.
Keywords:
dual modality; SPECT/MR; RGD peptide; small molecule; tumor targeting