PEGylated Carbon Nanocapsule: A Universal Reactor and Carrier for In Vivo Delivery of Hydrophobic and Hydrophilic Nanoparticles

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• 作者：Amritha Rammohan ; Gargi Mishra ; Binapani Mahaling ; Lokesh Tayal ; Ahana Mukhopadhyay ; Sanjay Gambhir ; Ashutosh Sharma ; Sri Sivakumar
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：January 13, 2016
• 年：2016
• 卷：8
• 期：1
• 页码：350-362
• 全文大小：717K
• ISSN：1944-8252

文摘

We have developed PEGylated mesoporous carbon nanocapsule as a universal nanoreactor and carrier for the delivery of highly crystalline hydrophobic/hydrophilic nanoparticles (NPs) which shows superior biocompatibility, dispersion in body fluids, good biodistribution and NPs independent cellular uptake mechanism. The hydrophobic/hydrophilic NPs without surface modification were synthesized in situ inside the cavities of mesoporous carbon capsules (200–850 nm). Stable and inert nature of carbon capsules in a wide range of reaction conditions like high temperature and harsh solvents, make it suitable for being used as nano/microreactors for the syntheses of a variety of NPs for bioimaging applications, such as NaYF₄:Eu³⁺(5%), LaVO₄:Eu³⁺(10%), GdVO₄:Eu³⁺(10%), Y₂O₃:Eu³⁺(5%), GdF₃:Tb³⁺(10%), Mo, Pt, Pd, Au, and Ag. Multiple types of NPs (Y₂O₃:Eu³⁺(5%) (hydrophobic) and GdF₃:Tb³⁺(10%) (hydrophilic)) were coloaded inside the carbon capsules to create a multimodal agent for magneto-fluorescence imaging. Our in vivo study clearly suggests that carbon capsules have biodistribution in many organs including liver, heart, spleen, lungs, blood pool, and muscles.