Directed Ortho-Lithiation of Aminophosphazenes: An Efficient Route to the Stereoselective Synthesis of P-Chiral Compounds

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• 作者：Mar铆a Casimiro ; Laura Roces ; Santiago Garc铆a-Granda ; Mar铆a Jos茅 Iglesias ; Fernando L贸pez Ortiz
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：May 17, 2013
• 年：2013
• 卷：15
• 期：10
• 页码：2378-2381
• 全文大小：281K
• 年卷期：v.15,no.10(May 17, 2013)
• ISSN：1523-7052

文摘

Ortho-directed lithiation of P,P-diphenylaminophosphazenes followed by electrophilic quench is described as an efficient process for synthesizing P-chiral ortho-functionalized derivatives in high yields and diastereoselectivities. The method allows the tunable preparation of structurally diverse enantiopure P-chiral compounds including phosphinic and phosphinothioic amides, phosphinic esters, phosphine oxides, and o-aminophosphines.