<
CENTER>
FIGR ID=jo062556wn00002> cribe/journals/joceah/72/i11/figures/jo062556wn00002.gif" ALIGN="left" HSPACE=5> |
Using dire
ct in
fusion ele
ctrospray ionization mass and tandem mass spe
ctrometri
c experiments [ESI-MS(/MS)], we have per
formed on-line monitoring o
f some rea
ctions used to
form Tröger's bases. Keyintermediates, either as
cationi
c spe
cies or as protonated
forms o
f neutral spe
cies, have been inter
ceptedand
chara
cterized. The role o
f urotropine as the methylene sour
ce in these rea
ctions has also been a
ccessed.Rea
ction pathways shown by ESI-MS(/MS) have been probed by gas-phase ion/mole
cule rea
ctions, andan expanded me
chanism
for Tröger's base
formation based on the mass spe
ctrometri
c data has beenelaborated.