Synthesis and Characterization of Lipid鈥揚olymer Hybrid Nanoparticles with pH-Triggered Poly(ethylene glycol) Shedding

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• 作者：Corbin Clawson ; Linh Ton ; Santosh Aryal ; Victoria Fu ; Sadik Esener ; Liangfang Zhang
• 刊名：Langmuir
• 出版年：2011
• 出版时间：September 6, 2011
• 年：2011
• 卷：27
• 期：17
• 页码：10556-10561
• 全文大小：827K
• 年卷期：v.27,no.17(September 6, 2011)
• ISSN：1520-5827

文摘

Novel lipid鈥損olymer hybrid nanoparticles are designed with a poly(ethylene glycol) (PEG) coating that is shed in response to a low pH trigger. This allows the nanoparticles to be stable during systemic circulation and at neutral pH, but destabilize and fuse with lipid membranes in acidic environments. The hybrid nanoparticles consist of a poly(lactic-co-glycolic acid) core with a lipid and lipid鈥揚EG monolayer shell. To make the hybrid nanoparticles pH sensitive, a lipid-(succinate)-mPEG conjugate is synthesized to provide a hydrolyzable PEG stealth layer that is shed off the particle surface at low pH. The pH-sensitivity of the nanoparticles is tunable using the molar concentration of the lipid-(succinate)-mPEG incorporated in the lipid shell of the particles. Possible uses of these pH-sensitive nanoparticles include aggregating in acidic tumor microenvironments, escaping acidified endosomes, or aggregating in deep lung tissue for improved inhalation administration.