Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

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• 作者：Mahmoud Labib ; Edward H. Sargent ; Shana O. Kelley
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：August 24, 2016
• 年：2016
• 卷：116
• 期：16
• 页码：9001-9090
• 全文大小：3844K
• 年卷期：0
• ISSN：1520-6890

文摘

Rapid progress in identifying biomarkers that are hallmarks of disease has increased demand for high-performance detection technologies. Implementation of electrochemical methods in clinical analysis may provide an effective answer to the growing need for rapid, specific, inexpensive, and fully automated means of biomarker analysis. This Review summarizes advances from the past 5 years in the development of electrochemical sensors for clinically relevant biomolecules, including small molecules, nucleic acids, and proteins. Various sensing strategies are assessed according to their potential for reaching relevant limits of sensitivity, specificity, and degrees of multiplexing. Furthermore, we address the remaining challenges and opportunities to integrate electrochemical sensing platforms into point-of-care solutions.