High Ionic Strength Glucose-Sensing Photonic Crystal

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• 作者：Vladimir L. Alexeev ; Anjal C. Sharma ; Alexander V. Goponenko ; Sasmita Das ; Igor K. Lednev ; Craig S. Wilcox ; David N. Finegold ; and Sanford A. Asher
• 刊名：Analytical Chemistry
• 出版年：2003
• 出版时间：May 15, 2003
• 年：2003
• 卷：75
• 期：10
• 页码：2316 - 2323
• 全文大小：218K
• 年卷期：v.75,no.10(May 15, 2003)
• ISSN：1520-6882

文摘

We demonstrate a colorimetric glucose recognition material consisting of a crystalline colloidal array embeddedwithin a polyacrylamide-poly(ethylene glycol) (PEG) hydrogel, or a polyacrylamide-15-crown-5 hydrogel, withpendent phenylboronic acid groups. We utilize a newmolecular recognition motif, in which boronic acid andPEG (or crown ether) functional groups are prepositionedin a photonic crystal hydrogel, such that glucose self-assembles these functional groups into a supramolecularcomplex. The formation of the complex results in anincrease in the hydrogel cross-linking, which for physiologically relevant glucose concentration blue shifts thephotonic crystal diffraction. The visually evident diffractioncolor shifts across the visible spectral region over physiologically important glucose concentration ranges. Thesematerials respond to glucose at physiological ionicstrengths and pH values and are selective in their modeof response for glucose over galactose, mannose, andfructose. Thus, we have developed a new recognition motiffor glucose that shows promise for the fabrication ofnoninvasive or minimally invasive in vivo glucose sensingfor patients with diabetes mellitus.