Solid/Liquid Palladium-Catalyzed Coupling of Haloaryls Using Alcohols as Reducing Agents: Kinetics and Process Optimization

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• 作者：Diana Gitis ; Sudip Mukhopadhyay ; Gadi Rothenberg ; and Yoel Sasson
• 刊名：Organic Process Research & Development
• 出版年：2003
• 出版时间：January 2003
• 年：2003
• 卷：7
• 期：1
• 页码：109 - 114
• 全文大小：84K
• 年卷期：v.7,no.1(January 2003)
• ISSN：1520-586X

文摘

Heterogeneous Pd-catalyzed coupling reaction of substitutedhalobenzenes to biphenyls is performed effectively in differentorganic solvents using an alcohol as the reducing agent in thepresence of a base and a catalytic amount of phase-transfer(PT) agent. The alcohol is oxidized to the respective aldehydeor ketone. Kinetic studies show that the reaction rate equationfits to second order in halobenzene. The effects of reactiontemperature, catalyst loading, base concentration, PTC concentration, and alcohol concentration and structure are studiedand discussed.