Lupane-Type Saponins from Leaves of Acanthopanax sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase
详细信息 查看全文
- 作者：Kazuma Yoshizumi ; Kaoru Hirano ; Hidehiro Ando ; Yasuaki Hirai ; Yoshiteru Ida ; Tomoko Tsuji ; Tamotsu Tanaka ; Kiyoshi Satouchi ; and Junji Terao
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2006
- 出版时间：January 25, 2006
- 年：2006
- 卷：54
- 期：2
- 页码：335 - 341
- 全文大小：125K
- 年卷期：v.54,no.2(January 25, 2006)
- ISSN：1520-5118
文摘
Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novelsaponin, 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-O-
-L-rhamnopyranosyl (1
4)-
-D-glucopyranosyl (16)--D-glucopyranoside, referred to as sessiloside, were isolated from a hot waterextract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpenetriglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract,respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition ofthe saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibilityof application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of obesity isdiscussed.Keywords: Lipase inhibitor; Acanthopanax sessiliflorus; lupane-type saponin; chiisanoside; sessiloside; obesity
-L-rhamnopyranosyl (14)--D-glucopyranosyl (16)--D-glucopyranoside, referred to as sessiloside, were isolated from a hot waterextract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpenetriglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract,respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition ofthe saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibilityof application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of obesity isdiscussed.Keywords: Lipase inhibitor; Acanthopanax sessiliflorus; lupane-type saponin; chiisanoside; sessiloside; obesity