Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novelsaponin, 3,4-
seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-
O-
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L-rhamnopyranosyl (1
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4)-
![](/images/gifchars/beta2.gif)
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D-glucopyranosyl (1
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6)-
![](/images/gifchars/beta2.gif)
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D-glucopyranoside, referred to as sessiloside, were isolated from a hot waterextract of
Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpenetriglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract,respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition ofthe saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibilityof application of the lupane-type saponins from
A. sessiliflorus leaves to the treatment of obesity isdiscussed.Keywords: Lipase inhibitor;
Acanthopanax sessiliflorus; lupane-type saponin; chiisanoside; sessiloside; obesity