Tandem Coordination, Ring-Opening, Hyperbranched Polymerization for the Synthesis of Water-Soluble Core鈥揝hell Unimolecular Transporters
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- 作者：Chris S. Popeney ; Maike C. Lukowiak ; Christoph B枚ttcher ; Boris Schade ; Pia Welker ; Dorothea Mangoldt ; Gesine Gunkel ; Zhibin Guan ; Rainer Haag
- 刊名：ACS Macro Letters
- 出版年：2012
- 出版时间：May 15, 2012
- 年：2012
- 卷：1
- 期：5
- 页码：564-567
- 全文大小：269K
- 年卷期：v.1,no.5(May 15, 2012)
- ISSN：2161-1653
文摘
A water-soluble molecular transporter with a dendritic core鈥搒hell nanostructure has been prepared by a tandem coordination, ring-opening, hyperbranched polymerization process. Consisting of hydrophilic hyperbranched polyglycerol shell grafted from hydrophobic dendritic polyethylene core, the transporter has a molecular weight of 951 kg/mol and a hydrodynamic diameter of 17.5 卤 0.9 nm, as determined by static and dynamic light scattering, respectively. Based on evidence from fluorescence spectroscopy, light scattering, and electron microscopy, the core鈥搒hell copolymer transports the hydrophobic guests pyrene and Nile red by a unimolecular transport mechanism. Furthermore, it was shown that the core鈥搒hell copolymer effectively transports the hydrophobic dye Nile red into living cells under extremely high and biologically relevant dilution conditions, which is in sharp contrast to a small molecule amphiphile. These results suggest potential applicability of such core鈥搒hell molecular transporters in the administration of poorly water-soluble drugs.