Luminescent Cell-Penetrating Pentadecanuclear Lanthanide Clusters
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- 作者：Dominique T. Thielemann ; Anna T. Wagner ; Esther R枚sch ; Dominik K. K枚lmel ; Joachim G. Heck ; Birgit Rudat ; Marco Neumaier ; Claus Feldmann ; Ute Schepers ; Stefan Br盲se ; Peter W. Roesky
- 刊名：The Journal of the American Chemical Society
- 出版年：2013
- 出版时间：May 22, 2013
- 年：2013
- 卷：135
- 期：20
- 页码：7454-7457
- 全文大小：282K
- 年卷期：v.135,no.20(May 22, 2013)
- ISSN：1520-5126
文摘
A novel pentadecanuclear lanthanide hydroxy cluster [{Ln15(渭3-OH)20(PepCO2)10(DBM)10Cl}Cl4] (Ln = Eu (1), Tb (2)) featuring the first example with peptoids as supporting ligands was prepared and fully characterized. The solid-state structures of 1 and 2 were established via single-crystal X-ray crystallography. ESI-MS experiments revealed the retention of the cluster core in solution. Although OH groups are present, 1 showed intense red fluorescence with 11(1)% absolute quantum yield, whereas the emission intensity and the quantum yield of 2 were significantly weaker. In vitro investigations on 1 and 2 with HeLa tumor cells revealed an accumulation of the clusters in the endosomal鈥搇yosomal system, as confirmed by confocal microscopy in the TRLLM mode. The cytotoxicity of 1 and 2 toward the HeLa cells is moderate.