Preparation of Water-Soluble Maleimide-Functionalized 3 nm Gold Nanoparticles: A New Bioconjugation Template

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• 作者：Jun Zhu ; Carmen Waengler ; R. Bruce Lennox ; Ralf Schirrmacher
• 刊名：Langmuir
• 出版年：2012
• 出版时间：April 3, 2012
• 年：2012
• 卷：28
• 期：13
• 页码：5508-5512
• 全文大小：297K
• 年卷期：v.28,no.13(April 3, 2012)
• ISSN：1520-5827

文摘

We present an efficient methodology to prepare maleimide-tethered, water-soluble gold nanoparticles (maleimide-AuNPs). The maleimide-AuNPs were prepared in the protected form and are readily recovered via a retro-Diels鈥揂lder reaction. The maleimide-AuNPs were fully characterized by ¹H NMR, TGA, TEM, and XPS and were determined to have a gold core with an average size of 3.2 卤 0.8 nm; each core contains about 1000 gold atoms and is surrounded by 30 maleimide-terminated ligands and 60 thiolated PEG ligands. The maleimide-AuNPs efficiently react with rhodamine 123 and cysteine and are a promising template for biological applications.