Antibody Molecules Discriminate between Crystalline Facets of a Gallium Arsenide Semiconductor

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• 作者：Arbel Artzy Schnirman ; Efrat Zahavi ; Hadas Yeger ; Ronit Rosenfeld ; Itai Benhar ; Yoram Reiter ; Uri Sivan
• 刊名：Nano Letters
• 出版年：2006
• 出版时间：September 2006
• 年：2006
• 卷：6
• 期：9
• 页码：1870 - 1874
• 全文大小：180K
• 年卷期：v.6,no.9(September 2006)
• ISSN：1530-6992

文摘

Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In thefollowing we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed togenerate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs (111A) facets asopposed to GaAs (100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on (111A) surfaces in a structurecomprising a mixture of (100) and (111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vispublished experiments with short and longer peptides.