文摘
Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In thefollowing we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed togenerate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs (111A) facets asopposed to GaAs (100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on (111A) surfaces in a structurecomprising a mixture of (100) and (111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vispublished experiments with short and longer peptides.