Aminodiols via Stereocontrolled Oxidation of Methyleneaziridines
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- 作者：Jared W. Rigoli ; Ilia A. Guzei ; Jennifer M. Schomaker
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：March 21, 2014
- 年：2014
- 卷：16
- 期：6
- 页码：1696-1699
- 全文大小：439K
- 年卷期：v.16,no.6(March 21, 2014)
- ISSN：1523-7052
文摘
A highly diastereoselective Ru-catalyzed oxidation/reduction sequence of bicyclic methyleneaziridines provides a facile route to complex 1-amino-2,3-diol motifs. The relative anti stereochemistry between the amine and the vicinal alcohol are proposed to result from 1,3-bischelation in the transition state by the C1 and C3 heteroatoms.