Bioactive Diterpene Derivatives from the Marine Sponge Spongionella sp.

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• 作者：Mostafa E. Rateb ; Wael E. Houssen ; Marc Schumacher ; William T. A. Harrison ; Marc Diederich ; Rainer Ebel ; Marcel Jaspars
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：August 28, 2009
• 年：2009
• 卷：72
• 期：8
• 页码：1471-1476
• 全文大小：223K
• 年卷期：v.72,no.8(August 28, 2009)
• ISSN：1520-6025

文摘

Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J−L (1, 2, 6), and a new diterpene, 3′-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3−5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds were tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.