Uniting C1-Ammonium Enolates and Transition Metal Electrophiles via Cooperative Catalysis: The Direct Asymmetric α-Allylation of Aryl Acetic Acid Esters
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- 作者：Kevin J. Schwarz ; Jessica L. Amos ; J. Cullen Klein ; Dung T. Do ; Thomas N. Snaddon
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：April 27, 2016
- 年：2016
- 卷：138
- 期：16
- 页码：5214-5217
- 全文大小：393K
- 年卷期：0
- ISSN：1520-5126
文摘
The direct, catalytic, asymmetric α-functionalization of acyclic esters constitutes a significant challenge in the area of asymmetric catalysis, particularly where the configurational integrity of the products is problematic. Through the unprecedented merger of two independent, yet complementary, catalysis events it has been possible to facilitate the direct asymmetric α-allylation of readily available aryl acetic acid esters. Since enantioselection is determined by the nucleophile, this conceptual approach to cooperative catalysis constitutes a potentially general solution to the direct catalytic asymmetric α-functionalization of acyclic esters.