A new series of organo
metallic rutheniu
m(II)-arene co
mpounds of the type RuCl
2(
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mages/gifchars/eta.gif" BORDER=0 >
6-arene)(phosphine)(phosphine = 1,3,5-triaza-7-phosphaada
mantane, PTA, and 3,7-diacetly-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane, DAPTA) with different potential hydrogen-bonding functionalities on the arene ligandhave been prepared and studied for their antitu
mor activity. Cell viability studies using the TS/A
mouseadenocarcino
ma cancer cell line and the nontu
morigenic HBL-100 hu
man
ma
mmary cell line, co
mbinedwith uptake deter
minations, are co
mpared to the nonfunctionalized analogues, previously shown to beactive on solid
metastasizing tu
mors. The reactivity of the functionalized RAPTA co
mpounds with a14-
mer oligonucleotide (established by
mass spectro
metry) has been rationalized by DFT calculations,which indicate that environ
mental factors are i
mportant.