Efficient Phosphodiester Cleaving Nanozymes Resulting from Multivalency and Local Medium Polarity Control

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• 作者：Marta Diez-Castellnou ; Fabrizio Mancin ; Paolo Scrimin
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：January 29, 2014
• 年：2014
• 卷：136
• 期：4
• 页码：1158-1161
• 全文大小：248K
• ISSN：1520-5126

文摘

The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.