Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents

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• 作者：Anthony Maher ; Denise M. Croker ; Colin C. Seaton ; 脜ke C. Rasmuson ; Benjamin K. Hodnett
• 刊名：Crystal Growth & Design
• 出版年：2014
• 出版时间：August 6, 2014
• 年：2014
• 卷：14
• 期：8
• 页码：3967-3974
• 全文大小：410K
• ISSN：1528-7505

文摘

The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5鈥?0 掳C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.