Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities

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• 作者：Yun-Seo Kil ; Seul-Ki Choi ; Yun-Sil Lee ; Mahtab Jafari ; Eun-Kyoung Seo
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2481-2487
• 全文大小：360K
• ISSN：1520-6025

文摘

Five new chalcones, 4,2鈥?4鈥?trihydroxy-3鈥?[(2E,5E)-7-methoxy-3,7-dimethyl-2,5-octadienyl]chalcone (1), (卤)-4,2鈥?4鈥?trihydroxy-3鈥?[(2E)-6-hydroxy-7-methoxy-3,7-dimethyl-2-octenyl]chalcone (2), 4,2鈥?4鈥?trihydroxy-3鈥?[(2E)-3-methyl-5-(1,3-dioxolan-2-yl)-2-pentenyl]chalcone (3), 2鈥?3鈥?furano-4-hydroxy-4鈥?methoxychalcone (4), and (卤)-4-hydroxy-2鈥?3鈥?(2,3-dihydro-2-methoxyfurano)-4鈥?methoxychalcone (5), were isolated from the aerial parts of Angelica keiskei Koidzumi together with eight known chalcones, 6鈥?b>13, which were identified as (卤)-4,2鈥?4鈥?trihydroxy-3鈥?[(6E)-2-hydroxy-7-methyl-3-methylene-6-octenyl]chalcone (6), xanthoangelol (7), xanthoangelol F (8), xanthoangelol G (9), 4-hydroxyderricin (10), xanthoangelol D (11), xanthoangelol E (12), and xanthoangelol H (13), respectively. Chalcones 1鈥?b>13 were evaluated for their promoter activity on heat shock protein 25 (hsp25, murine form of human hsp27). Compounds 1 and 6 activated the hsp25 promoter by 21.9- and 29.2-fold of untreated control at 10 渭M, respectively. Further protein expression patterns of heat shock factor 1 (HSF1), HSP70, and HSP27 by 1 and 6 were examined. Compound 6 increased the expression of HSF1, HSP70, and HSP27 by 4.3-, 1.5-, and 4.6-fold of untreated control, respectively, without any significant cellular cytotoxicities, whereas 1 did not induce any expression of these proteins. As a result, 6 seems to be a prospective HSP inducer.