Carbohydrates in Supramolecular Chemistry

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• 作者：Martina Delbianco ; Priya Bharate ; Silvia Varela-Aramburu ; Peter H. Seeberger
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：February 24, 2016
• 年：2016
• 卷：116
• 期：4
• 页码：1693-1752
• 全文大小：4371K
• 年卷期：
  Martina Delbianco received her Master degree in chemistry from the University of Milan in 2011. In 2012 she joined Prof. David Parker at Durham University, where she obtained her Ph.D. in 2014 with a thesis focused on highly emissive Eu(III) complexes for biological assays. Since 2015 she has been working as a postdoctoral fellow in the group of Prof. Peter Seeberger. Her current research relates to automated synthesis of oligosaccharides for structural and dynamics investigation.
  Priya Bharate received her B.Sc. (2008) and M.Sc. degrees (2011) in Chemistry from Pune University, India. After working at Dow Chemical Int. Pvt. Ltd., Pune, INDIA, she joined the group of Dr. R. Kikkeri as a Jr. Research Fellow at Indian Institute of Science Education & Research (IISER), Pune, India. She is a Ph.D. candidate under the supervision of Prof. Seeberger. Her research focuses on the design of multivalent carbohydrate scaffolds and the development of nanomaterials with biomedical applications.
  Silvia Varela-Aramburu obtained her chemistry degree from the University of Vigo with a master thesis on the synthesis of plasmonic nanoparticles from the Free University, Berlin. She is currently a Ph.D. candidate under the supervision of Prof. Peter Seeberger. Her research is focused on the development of glycosylated nanoparticles for biomedical applications.
  Prof. Peter H. Seeberger studied chemistry in Erlangen (Germany) and completed his Ph.D. in biochemistry in Boulder (CO). After performing research at the Sloan-Kettering Cancer Center in New York, he built an independent research program at MIT where he was promoted to Firmenich Associate Professor with tenure after just four years. After six years as Professor at ETH Zurich, he assumed positions as Director at the Max-Planck Institute in Potsdam and Professor at the Free University Berlin. His research covers the glycosciences from chemistry to immunology as well as flow chemistry.
• ISSN：1520-6890

文摘

Carbohydrates are involved in a variety of biological processes. The ability of sugars to form a large number of hydrogen bonds has made them important components for supramolecular chemistry. We discuss recent advances in the use of carbohydrates in supramolecular chemistry and reveal that carbohydrates are useful building blocks for the stabilization of complex architectures. Systems are presented according to the scaffold that supports the glyco-conjugate: organic macrocycles, dendrimers, nanomaterials, and polymers are considered. Glyco-conjugates can form host–guest complexes, and can self-assemble by using carbohydrate–carbohydrate interactions and other weak interactions such as π–π interactions. Finally, complex supramolecular architectures based on carbohydrate–protein interactions are discussed.