Gadolinium-Based Hybrid Nanoparticles as a Positive MR Contrast Agent

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• 作者：Hiroki Hifumi ; Seiichi Yamaoka ; Akihiro Tanimoto ; Daniel Citterio ; Koji Suzuki
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：November 29, 2006
• 年：2006
• 卷：128
• 期：47
• 页码：15090 - 15091
• 全文大小：114K
• 年卷期：v.128,no.47(November 29, 2006)
• ISSN：1520-5126

文摘

A new nanoparticulate inorganic-organic hybrid-type positive contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO₄ inorganic core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large number of water molecules in proximity of the core and toxicity reduction in in-vivo studies. This PGP/dextran-K01 nanoparticle has high r₁ and r₂ values and a significantly low r₂/r₁ value, 1.1, which is unprecedented and which is the lowest value among existing nanoparticulate CAs indicating that PGP/dextran-K01 is a positive contrast agent. Because of this low r₂/r₁ value and the nanoparticulate shape, PGP/dextran-K01 will be a useful clinical substitute for negative CAs based on iron oxides.