Development of Vizantin, a Safe Immunostimulant, Based on the Structure鈥揂ctivity Relationship of Trehalose-6,6鈥?dicorynomycolate
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- 作者：Hirofumi Yamamoto ; Masataka Oda ; Mayo Nakano ; Naoyuki Watanabe ; Kenta Yabiku ; Masahiro Shibutani ; Masahisa Inoue ; Hiroshi Imagawa ; Masahiro Nagahama ; Seiichiro Himeno ; Kojun Setsu ; Jun Sakurai ; Mugio Nishizawa
- 刊名：Journal of Medicinal Chemistry
- 出版年：2013
- 出版时间：January 10, 2013
- 年：2013
- 卷：56
- 期：1
- 页码：381-385
- 全文大小：311K
- 年卷期：v.56,no.1(January 10, 2013)
- ISSN：1520-4804
文摘
Vizantin, 6,6鈥?bis-O-(3-nonyldodecanoyl)-伪,伪鈥?trehalose, was developed as a safe immunostimulator on the basis of a structure鈥揳ctivity relationship (SAR) study with trehalose 6,6鈥?dicorynomycolate (TDCM). It was possible to synthesize vizantin on a large scale more easily than in the case of TDCM, and the compound exhibited more potent prophylactic effect on experimental lung metastasis of B16鈥揊0 melanoma cells. Because vizantin stimulated human macrophages, it is a promising candidate for clinical application.