Total Synthesis and Bioactivity of Resolvin E2

详细信息    查看全文

• 作者：Seiji Ogawa ; Daisuke Urabe ; Yoshiyuki Yokokura ; Hiroyuki Arai ; Makoto Arita ; Masayuki Inoue
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：August 20, 2009
• 年：2009
• 卷：11
• 期：16
• 页码：3602-3605
• 全文大小：253K
• 年卷期：v.11,no.16(August 20, 2009)
• ISSN：1523-7052

文摘

Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.