Enterodiol and Enterolactone Modulate the Immune Response by Acting on Nuclear Factor-κB (NF-κB) Signaling

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• 作者：Emanuela Corsini ; Mario Dell’ ; Agli ; Alessandra Facchi ; Emma De Fabiani ; Laura Lucchi ; Maria Serena Boraso ; Marina Marinovich ; Corrado L. Galli
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2010
• 出版时间：June 9, 2010
• 年：2010
• 卷：58
• 期：11
• 页码：6678-6684
• 全文大小：813K
• 年卷期：v.58,no.11(June 9, 2010)
• ISSN：1520-5118

文摘

Lignan-rich whole-grain cereals, beans, berries, and nuts show protective effects against a variety of chronic diseases, including cancer. Lignans are converted by intestinal microflora to enterolactone (EL) and its oxidation product enterodiol (ED). To investigate the immunomodulatory effect of EL and ED in human cells, peripheral blood lymphocytes were treated with increasing physiologically relevant concentrations of EL and ED (0−1000 μM) and stimulated with lipopolysaccharide (LPS) and anti-CD3 plus anti-CD28 monoclonal antibodies. A dose-related inhibition of cell proliferation and cytokine production was observed, with EL being the most active. Molecular investigations in THP-1 cells showed that both EL and ED prevented inhibitory-κB (I-κB) degradation and nuclear factor-κB (NF-κB) activation, which in turn resulted in decreased tumor necrosis factor-α (TNF-α) production. EL and ED were also able to pass the intestinal barrier and modulate cytokine production. The findings of the present study reveal potential mechanisms that could explain some in vivo beneficial effects of lignans.