A Novel Dewar-Like Reactor for Maintaining Constant Heat and Enhancing Product Yields during Microwave-Assisted Organic Syntheses

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• 作者：Satoshi Horikoshi ; Atsushi Osawa ; Yindee Suttisawat ; Masahiko Abe ; Nick Serpone
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：November 19, 2010
• 年：2010
• 卷：14
• 期：6
• 页码：1453-1456
• 全文大小：154K
• 年卷期：v.14,no.6(November 19, 2010)
• ISSN：1520-586X

文摘

A novel microwave reaction vessel is herein proposed for maintaining constant heat during microwave-assisted organic syntheses. The structure of the vessel is Dewar-like in that it prevents conduction of microwave-generated heat in dielectric substrates into the surroundings. The potential of the double-walled vacuum-filled vessel has been examined for the absence of thermal gradients in aqueous media (homogeneous media) and in the synthesis of biphenyl in a nonpolar solvent (heterogeneous media) involving the Suzuki−Miyaura coupling reaction. The efficiency of the microwave-assisted organic synthesis was enhanced significantly (6- to 7-fold) with this double-walled vessel relative to the conventional single-walled reactor vessel currently used in commercial microwave chemical devices.