Low-Cost Rapid Prototyping of Whole-Glass Microfluidic Devices
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- 作者：Po Ki Yuen ; Vasiliy N. Goral
- 刊名：Journal of Chemical Education
- 出版年：2012
- 出版时间：September 11, 2012
- 年：2012
- 卷：89
- 期：10
- 页码：1288-1292
- 全文大小：288K
- 年卷期：v.89,no.10(September 11, 2012)
- ISSN：1938-1328
文摘
A low-cost, straightforward, rapid prototyping of whole-glass microfluidic devices is presented using glass-etching cream that can be easily purchased in local stores. A self-adhered vinyl stencil cut out by a desktop digital craft cutter was used as an etching mask for patterning microstructures in glass using the glass-etching cream. A specific calcium-assisted glass-to-glass bonding at 115 掳C in a standard laboratory oven for 2 h was used to complete the whole-glass microfluidic device fabrication process. Various functional microfluidic devices were demonstrated with this rapid prototyping method. The complete fabrication process from device-design concept to working device can be completed in approximately 3 to 4 h in a regular laboratory setting without the need of expensive equipment and the need to handle extremely hazardous hydrofluoric acid. This whole-glass rapid prototyping method will be of immediate benefit to the microfluidic and nano- or micro-fabrication community in potentially saving time and costs associated with prototyping of whole-glass microfluidic devices. Also, it lowers the barriers to new entrants to the field of microfluidics and could be useful at both undergraduate and graduate levels for hands-on microfabrication and microfluidic courses with limited resources for expensive and high tech equipment.