Gageotetrins A–C, Noncytotoxic Antimicrobial Linear Lipopeptides from a Marine Bacterium Bacillus subtilis
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- 作者：Fakir Shahidullah Tareq ; Min Ah Lee ; Hyi-Seung Lee ; Yeon-Ju Lee ; Jong Seok Lee ; Choudhury M. Hasan ; Md. Tofazzal Islam ; Hee Jae Shin
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：February 7, 2014
- 年：2014
- 卷：16
- 期：3
- 页码：928-931
- 全文大小：302K
- ISSN：1523-7052
文摘
Gageotetrins A鈥揅 (1鈥?b>3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1鈥?b>3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1鈥?b>3 displayed good antimicrobial activities with MIC values of 0.01鈥?.06 渭M. However, these compounds failed to register any cytotoxicity (GI50 > 30 渭g/ml) against human cancer cell lines.