Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis

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• 作者：Fakir Shahidullah Tareq ; Ji Hye Kim ; Min Ah Lee ; Hyi-Seung Lee ; Yeon-Ju Lee ; Jong Seok Lee ; Hee Jae Shin
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：March 16, 2012
• 年：2012
• 卷：14
• 期：6
• 页码：1464-1467
• 全文大小：202K
• 年卷期：v.14,no.6(March 16, 2012)
• ISSN：1523-7052

文摘

Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey鈥檚 and Mosher鈥檚 methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI₅₀ values of 25.18 and 17.78 渭g/mL, respectively.