Meroterpenoids from a Tropical Dysidea sp. Sponge
详细信息 查看全文
- 作者：Chang-Kwon Kim ; Jung-Kyun Woo ; Seong-Hwan Kim ; Eunji Cho ; Yeon-Ju Lee ; Hyi-Seung Lee ; Chung J. Sim ; Dong-Chan Oh ; Ki-Bong Oh ; Jongheon Shin
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：November 25, 2015
- 年：2015
- 卷：78
- 期：11
- 页码：2814-2821
- 全文大小：362K
- ISSN：1520-6025
文摘
Six new meroterpenoids (1鈥?b>6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 4鈥?b>6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na+/K+-ATPase.