BODIPY鈥揅oumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models
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- 作者：Hoyeon Lee ; Zhigang Yang ; Youngjin Wi ; Tae Woo Kim ; Peter Verwilst ; Yun Hak Lee ; Ga-in Han ; Chulhun Kang ; Jong Seung Kim
- 刊名：Bioconjugate Chemistry
- 出版年：2015
- 出版时间：December 16, 2015
- 年：2015
- 卷：26
- 期：12
- 页码：2474-2480
- 全文大小：427K
- ISSN：1520-4812
文摘
An endoplasmic reticulum (ER) membrane-selective chemosensor composed of BODIPY and coumarin moieties and a long alkyl chain (n-C18) was synthesized. The emission ratio of BODIPY to coumarin depends on the solution viscosity. The probe is localized to the ER membrane and was applied to reveal the reduced ER membrane fluidity under ER stress conditions.