Gold(I)-Catalyzed Intramolecular Hydroamination of Alkyne with Trichloroacetimidates

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• 作者：Ji-Eun Kang ; Hak-Beom Kim ; Jin-Woo Lee ; Seunghoon Shin
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：August 3, 2006
• 年：2006
• 卷：8
• 期：16
• 页码：3537 - 3540
• 全文大小：77K
• 年卷期：v.8,no.16(August 3, 2006)
• ISSN：1523-7052

文摘

A study on the gold (I)-catalyzed intramolecular hydroamination of trichloroacetimidates derived from propargyl and homopropargyl alcoholsis described. In the presence of 2-5 mol % of cationic Au(I) complex, a variety of trichloroacetimidates undergo efficient hydroaminationunder an exceptionally mild condition. An orthogonality of the current catalytic protocol with those using a stoichiometric electrophile as wellas a preliminary synthetic application as a stable precursor of 2-acylamino-1,3-diene has been demonstrated.