Room-Temperature Organocatalytic Cycloaddition of Azides with 尾-Keto Sulfones: Toward Sulfonyl-1,2,3-triazoles
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- 作者：Maiara T. Saraiva ; Gabriel P. Costa ; Nat谩lia Seus ; Ricardo F. Schumacher ; Gelson Perin ; M谩rcio W. Paix茫o ; Rafael Luque ; Diego Alves
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：December 18, 2015
- 年：2015
- 卷：17
- 期：24
- 页码：6206-6209
- 全文大小：361K
- ISSN：1523-7052
文摘
Organocatalytic enamine鈥揳zide [3 + 2] cycloadditions between 尾-keto sulfones and aryl azides can be performed at room temperature in good to excellent yields of products in the presence of catalytic amounts of pyrrolidine (5 mol %). The proposed organocatalytic methodology was found to be applicable to 尾-keto arylsulfones containing a range of substituents. A wide variety of aryl azides also work. Basically, this constitutes a remarkably efficient protocol for the synthesis of novel 1,2,3-triazole compounds.