Iridium-Catalyzed Asymmetric Ring-Opening of Azabicyclic Alkenes with Phenols

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• 作者：Shai Fang ; Xiuli Liang ; Yuhua Long ; Xiaolu Li ; Dingqiao Yang ; Sanyong Wang ; Chunrong Li
• 刊名：Organometallics
• 出版年：2012
• 出版时间：April 23, 2012
• 年：2012
• 卷：31
• 期：8
• 页码：3113-3118
• 全文大小：282K
• 年卷期：v.31,no.8(April 23, 2012)
• ISSN：1520-6041

文摘

The asymmetric ring-opening of azabicyclic alkenes with a variety of phenols is investigated using an iridium catalyst generated in situ from 2.5 mol % of [Ir(COD)Cl]₂ and 5.0 mol % of (S)-BINAP, which afforded the corresponding 1,2-trans-phenoxyamino products in excellent yield (up to 92%) with moderate to good enantioselectivities (up to 98% ee). The trans-configuration of the product 4b was confirmed by X-ray crystallography.