Sulfoximine-Directed Ruthenium-Catalyzed ortho-C鈥揌 Alkenylation of (Hetero)Arenes: Synthesis of EP3 Receptor Antagonist Analogue
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- 作者：M. Ramu Yadav ; Raja K. Rit ; Majji Shankar ; Akhila K. Sahoo
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：July 3, 2014
- 年：2014
- 卷：79
- 期：13
- 页码：6123-6134
- 全文大小：640K
- ISSN：1520-6904
文摘
The reusable sulfoximine directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C鈥揌 alkenylation of arenes and heteroarenes with acrylates and 伪,尾-unsaturated ketones/vinyl sulfone is shown. The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinolinones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue.