DNA Binding and Anti-Cancer Activity of Redox-Active Heteroleptic Piano-Stool Ru(II), Rh(III), and Ir(III) Complexes Containing 4-(2-Methoxypyridyl)phenyldipyrromethene

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• 作者：Rakesh Kumar Gupta ; Rampal Pandey ; Gunjan Sharma ; Ritika Prasad ; Biplob Koch ; Saripella Srikrishna ; Pei-Zhou Li ; Qiang Xu ; Daya Shankar Pandey
• 刊名：Inorganic Chemistry
• 出版年：2013
• 出版时间：April 1, 2013
• 年：2013
• 卷：52
• 期：7
• 页码：3687-3698
• 全文大小：612K
• 年卷期：v.52,no.7(April 1, 2013)
• ISSN：1520-510X

文摘

The synthesis of four novel heteroleptic dipyrrinato complexes [(畏⁶-arene)RuCl(2-pcdpm)] (畏⁶-arene = C₆H₆, 1; C₁₀H₁₄, 2) and [(畏⁵-C₅Me₅)MCl(2-pcdpm)] (M = Rh, 3; Ir, 4) containing a new chelating ligand 4-(2-methoxypyridyl)-phenyldipyrromethene (2-pcdpm) have been described. The complexes 1鈥?b>4 have been fully characterized by various physicochemical techniques, namely, elemental analyses, spectral (ESI-MS, IR, ¹H, ¹³C NMR, UV/vis) and electrochemical studies (cyclic voltammetry (CV) and differential pulse voltammetry (DPV)). Structures of 3 and 4 have been determined crystallographically. In vitro antiproliferative and cytotoxic activity of these complexes has been evaluated by trypan blue exclusion assay, cell morphology, apoptosis, acridine orange/ethidium bromide (AO/EtBr) fluorescence staining, and DNA fragmentation assay in Dalton lymphoma (DL) cell lines. Interaction of 1鈥?b>4 with calf thymus DNA (CT DNA) has also been supported by absorption titration and electrochemical studies. Our results suggest that in vitro antitumor activity of 1鈥?b>4 lies in the order 2 > 1 > 4 > 3.